Affymetrix: GeneChip® arrays enable scientists to attain ambitious goals from identifying genetic variations associated with disease to discovering new drug targets.
Location: NSC 518
Contact: Level III Sonja S. Young; 404-413-5370 or John Houghton; 404-65(404) 413-5390
Applications: Leveraging technologies adapted from the
semiconductor industry, the manufacture of GeneChip arrays uses photolithography
and solid-phase chemistry to produce arrays containing hundreds of thousands
of oligonucleotide probes packed at extremely high densities. The probes
are designed to maximize sensitivity, specificity, and reproducibility,
allowing consistent discrimination between specific and background signals,
and between closely related target sequences.
Attesting to their powerful capabilities, GeneChip arrays are applied
in a wide variety of DNA and mRNA analyses. Recent analytical accomplishments
include the elucidation of interactions between signaling pathways involved
in development, the discovery of a new class of leukemia, and the development
of new assays to track drug metabolism.
Website: Affymetrix Gene Chip system