Applied Biosystems: The 4800 is one of the most sensitive protein / biomarker discovery systems currently available using time-of-flight MS/MS technology.
Location: NSC 438A
Contact: Level III - Hyuk-Kyu Seoh ; 404-413-5370
Applications:
•Powerful RDA features of GPS Explorer™ Software for flexible acquisition and data processing.
• Unmatched sensitivity (subfemtomole) in both MS and MS/SM modes
• Enhanced Precursor Ion Selection
• Profile biomolecules directly on tissue samples; sample (tissue section, whole organs or whole animals) can be analyzed directly, no extraction of compounds is required and no sample labeling required.
•ProteinPilot Software 2.0 enables searching for over 100 post-translational modifications, up to 45 work-up modifications and all amino acid substitutions, genetic variants and unexpected cleavages.
• Enhanced Mass accuracy. Using an internal standard, 2.5 ppm mass accuracy is achieved, increasing confidence in protein ID.
• Quantitation of Specific proteins using iTRAQ reagents. iTRAQ reagents are multiplexed sets of 8 isobaric reagents which allows for sophisticated time course studies, absolute quantitation and monitors qualitative protein changes under different physiological conditions.
• Biomarker Discovery using iTRAQ reagents. Besides biomarker identification, iTRAQ allows quantitation that would indicate which proteins are changing in response to a given environmental change, drug treatment or disease.
• Post-source-decay for peptide sequencing. MALDI CID capability for protein sequence determination and structural analysis.
Website: 4800 Plus MALDI TOF/TOF Analyzer